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MR imaging and MR spectroscopy of human during physical stress (MR spectroscopy imaging, MR diffusometry, MR relaxometry etc.)
Šedivý, Petr ; Hájek, Milan (advisor) ; Haberlová, Jana (referee) ; Vymazal, Josef (referee)
The dissertation is concerned to in vivo phosphorus MR spectroscopy (31 P MRS) and 1 H MR imaging (MRI) of muscle in combination with physical workload. The theoretical part of the thesis describes methodology of 31 P MRS measurement and its clinical use in research of metabolic changes in diabetes, heart failure and peripheral artery disease (PAD). The results of the thesis are divided into methodical and clinical parts. Methodical results deal with the construction of experimental equipment, software modification and development, and show of the reproducibility of the dynamic 31 P MRS. The MRI after exercise was used to the describe involvement of the individual calf muscles to muscle contraction during pedal movement in MR compatible ergometer. The first part of the clinical results of the thesis describes changes in muscle metabolism during diabetes and critical ischemia. In patients with critical ischemia the effect of treatment by angioplasty or transplantation of mesenchymal stem cells was evaluated. In the second part of the clinical results the metabolism of patients with heart failure complicated by sideropenia was studied. In these patients the effect of experimental treatment by iron carboxymaltose was described.
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Muscle metabolism and its effect on physical condition in patients with chronic renal failure receiving hemodialysis
Brůhová, Zuzana ; Mahrová, Andrea (advisor) ; Táborský, Petr (referee)
Title: Muscle metabolism and its effect on physical condition in patients with chronic renal failure receiving hemodialysis Objective: Assess the status of muscle metabolism in patients starting hemodialysis and patients receiving hemodialysis long time, to determine some changes in muscle metabolism in both groups in the time period and ultimately assess its impact on physical condition and quality of life of hemodialysis patients. Method: Fill anamnestic questionnaire and examination of body composition using bioimpedence device (BCM) in the group of patients with chronic renal failure who are beginning to be treated with hemodialysis and a group of patients treated with hemodialysis for several years. Compare the results of both groups. To obtain additional information from medical records. Results: It was found that hemodialysis therapy affects the status of muscle metabolism in terms of reducing muscle mass (LTM). The dependence of LTM, however, the duration of hemodialysis treatment assays. The study showed that if patients are nutritionally stable and regularly engaged in some physical activity, loss of muscle mass is lower than in individuals who have a passive way of life. Keywords: chronic renal failure, hemodilysis, muscle metabolism, physical condition
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MR imaging and MR spectroscopy of human during physical stress (MR spectroscopy imaging, MR diffusometry, MR relaxometry etc.)
Šedivý, Petr ; Hájek, Milan (advisor) ; Haberlová, Jana (referee) ; Vymazal, Josef (referee)
The dissertation is concerned to in vivo phosphorus MR spectroscopy (31 P MRS) and 1 H MR imaging (MRI) of muscle in combination with physical workload. The theoretical part of the thesis describes methodology of 31 P MRS measurement and its clinical use in research of metabolic changes in diabetes, heart failure and peripheral artery disease (PAD). The results of the thesis are divided into methodical and clinical parts. Methodical results deal with the construction of experimental equipment, software modification and development, and show of the reproducibility of the dynamic 31 P MRS. The MRI after exercise was used to the describe involvement of the individual calf muscles to muscle contraction during pedal movement in MR compatible ergometer. The first part of the clinical results of the thesis describes changes in muscle metabolism during diabetes and critical ischemia. In patients with critical ischemia the effect of treatment by angioplasty or transplantation of mesenchymal stem cells was evaluated. In the second part of the clinical results the metabolism of patients with heart failure complicated by sideropenia was studied. In these patients the effect of experimental treatment by iron carboxymaltose was described.
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Muscle metabolism and its effect on physical condition in patients with chronic renal failure receiving hemodialysis
Brůhová, Zuzana ; Mahrová, Andrea (advisor) ; Táborský, Petr (referee)
Title: Muscle metabolism and its effect on physical condition in patients with chronic renal failure receiving hemodialysis Objective: Assess the status of muscle metabolism in patients starting hemodialysis and patients receiving hemodialysis long time, to determine some changes in muscle metabolism in both groups in the time period and ultimately assess its impact on physical condition and quality of life of hemodialysis patients. Method: Fill anamnestic questionnaire and examination of body composition using bioimpedence device (BCM) in the group of patients with chronic renal failure who are beginning to be treated with hemodialysis and a group of patients treated with hemodialysis for several years. Compare the results of both groups. To obtain additional information from medical records. Results: It was found that hemodialysis therapy affects the status of muscle metabolism in terms of reducing muscle mass (LTM). The dependence of LTM, however, the duration of hemodialysis treatment assays. The study showed that if patients are nutritionally stable and regularly engaged in some physical activity, loss of muscle mass is lower than in individuals who have a passive way of life. Keywords: chronic renal failure, hemodilysis, muscle metabolism, physical condition
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